ABSTRACT
@EN The organ specific autoimmune diseases may occur in the same individual. Polyglandular autoimmune syndrome designates the dysfunction of endocrine and nonendocrine system involving two or more oragans on the basis of autoimmunity. This
syndrome
is
usually classified into three classes. Type Ⅲpolyglandular autoimmune syndrome is defined by the occurrence in the same individual of two or more of the followings: autoimmune thyroid disease, pernicious anemia, insulin dependent diabetes, and
other
organ specific autoimmune disease not falling into class Ⅰ or class Ⅱ categories.
A 29-year-old man developed pernicious anemia and insulin dependent diabetes during the treatment of Graves' disease with antithyroid drug (propylthiouracil). He developed a spontaneous pancytopenia during the course of Graves' disease that
showed
euthyroid state with antithyroid drug, propylthiouracil. Bone marrow and peripheral blood revealed the findings compatible with megaloblastic anemia. The blood level of vitamin B12 was low and the serum titers of antibodies to gastric parietal
cell
and
intrinsic factor was high. About two years after the treatment of pernicious anemia, he developed insulin dependent diabetes mellitus. The ICSA (islet cell surface antibody) and ICA (islet cell antibody) were negative. His HLA serotype was A24,
A11,
Bw60, Cw3, DRw15, DRw17.
We report here a case of polyglandular autoimmune syndrome, type Ⅲ manifesting Graves' disease, pernicious anemia, and insulin dependent diabetes mellitus. (J Kor Soc Endocrinol 8:211~215, 1993)
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